The course emphasizes intermolecular interactions of biological macromolecules such as proteins with other molecules. The first part of the course addresses fundamental chemical concepts underlying these types of noncovalent interactions, description of various protein complexes, and a hands-on application of molecular docking protocols to calculate structures of complexes using data from the biochemical literature. The second part of the course focuses on student independent projects utilizing protein structures and data from the literature. Molecular docking is used as a tool to test predictions about the wider biological implications of altering biomolecular interactions.
Prerequisites: CHEM 251, 460 is preferred, or permission of the instructor.