This course explores in greater breadth and depth the body's acute responses and long-term adaptations to exercise. Students read original research to explore the cellular and molecular mechanisms by which physical activity and exercise training affect health and chronic disease. Environmental challenges to human activity caused by heat, cold, altitude, hyperbaric conditions, and microgravity are investigated in lectures and/or laboratories. Topics also may include the endocrine control of substrate metabolism, biochemical markers of fitness and metabolism, mitochondrial biogenesis, plasticity of muscle fiber types, and cardiovascular dynamics and autonomic regulation of blood flow, fluid homeostasis, and others. Students will work in small collaborations to identify a relevant question, research the literature, and design and complete a research thesis.
Prerequisites: EXSC 329